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1.Asian Pac J Cancer Prev. 2012;13(8):4147-51.
2.Mol Cancer Res. 2010 Mar;8(3):421-32.
Phosphoinositide-dependent kinase 1 (PDPK1, PDK1) is a serine/threonine protein kinase integral to the function of the PI 3-K/Akt signaling pathway. PDK1 and mTORC2 both phosphorylate and activate PKB/Akt, ensuring a cellular response to stimuli such as growth factors and insulin signaling. Akt is the main effector of PDK1.
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