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1. J Clin Endocrinol Metab. 2006 Mar;91(3):1056-61.
2. Sci STKE. 2006 Oct 17;2006(357):re13.
3. Am J Hum Genet. 2010 Jun 11;86(6):839-49.The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. |
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